Hiromi Sakai Selected Research

Blood Substitutes (Artificial Blood)

1/2022	Bioinspired carbon monoxide delivery using artificial blood attenuates the progression of obliterative bronchiolitis via suppression of macrophage activation by IL-17A.
11/2021	Liposome-encapsulated hemoglobin (HbV) transfusion rescues rats undergoing progressive lethal 85% hemorrhage as a result of an anti-arrhythmogenic effect on the myocardium.
8/2018	Intravenous injection of artificial red cells and subsequent dye laser irradiation causes deep vessel impairment in an animal model of port-wine stain.
4/2017	Artificial Red Blood Cells as Potential Photosensitizers in Dye Laser Treatment Against Port-Wine Stains.
4/2015	Potential electron mediators to extract electron energies of RBC glycolysis for prolonged in vivo functional lifetime of hemoglobin vesicles.

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Hiromi Sakai Research Topics

Disease

19	Hemorrhagic Shock 06/2022 - 09/2002
11	Hemorrhage 06/2022 - 04/2011
6	Inflammation (Inflammations) 03/2022 - 03/2007
6	Hypoxia (Hypoxemia) 01/2022 - 05/2003
5	Port-Wine Stain (Nevus Flammeus) 03/2022 - 03/2017
4	Infections 01/2022 - 10/2008
4	Neoplasms (Cancer) 12/2021 - 01/2009
4	Shock 11/2018 - 09/2004
3	Anemia 06/2022 - 10/2019
3	Fibrosis (Cirrhosis) 01/2022 - 02/2011
3	Poisoning 01/2022 - 10/2021
3	Wounds and Injuries (Trauma) 10/2019 - 01/2016
3	Reperfusion Injury 01/2019 - 02/2009
3	Fetal Hypoxia 07/2017 - 10/2012
2	Acute Kidney Injury (Acute Renal Failure) 01/2022 - 12/2021
2	Acidosis 01/2022 - 01/2019
2	Pancreatitis 11/2018 - 01/2016
2	Body Weight (Weight, Body) 11/2018 - 07/2014
2	Fetal Growth Retardation (Intrauterine Growth Retardation) 07/2017 - 10/2015
2	Pre-Eclampsia (Preeclampsia) 07/2017 - 10/2015
2	Lung Injury 01/2016 - 09/2009
2	Hyperlipidemias (Hyperlipidemia) 01/2015 - 01/2007
2	Anaphylaxis (Anaphylactic Shock) 10/2012 - 01/2007
2	Liver Cirrhosis (Hepatic Cirrhosis) 02/2011 - 11/2010
1	Methemoglobinemia 04/2022
1	Burns 03/2022
1	Chronic Renal Insufficiency 01/2022
1	Bronchiolitis 01/2022
1	Postpartum Hemorrhage 11/2021
1	Exsanguination 01/2020
1	Death (Near-Death Experience) 01/2019

Drug/Important Bio-Agent (IBA)

36	Hemoglobins (Hemoglobin)IBA 03/2022 - 07/2002
19	Oxygen (Dioxygen)IBA 06/2022 - 07/2002
9	Carbon MonoxideIBA 01/2022 - 05/2009
6	Liposomes (Liposome)IBA 12/2021 - 01/2009
5	Photosensitizing Agents (Photosensitizers)IBA 03/2022 - 03/2017
5	Blood Substitutes (Artificial Blood)IBA 01/2022 - 04/2015
5	Human Serum Albumin FDA LinkGeneric 01/2021 - 02/2003
5	SolutionsIBA 01/2019 - 05/2003
5	CytokinesIBA 01/2016 - 02/2012
4	AlbuminsIBA 06/2022 - 09/2004
4	MethemoglobinIBA 01/2022 - 01/2009
4	Pharmaceutical PreparationsIBA 12/2021 - 01/2016
3	liposome-encapsulated hemoglobinIBA 06/2022 - 01/2019
3	Cyanides (Isocyanides)IBA 01/2022 - 10/2021
3	AntidotesIBA 01/2022 - 10/2021
3	Therapeutic UsesIBA 01/2022 - 08/2014
3	SuspensionsIBA 12/2021 - 07/2014
2	Free RadicalsIBA 03/2022 - 04/2015
2	Phenobarbital (Luminal)FDA Link 01/2022 - 10/2008
2	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 01/2022 - 10/2021
2	EnzymesIBA 01/2022 - 02/2009
2	Lactic Acid (Lactate)FDA LinkGeneric 01/2021 - 12/2006
2	Proteins (Proteins, Gene)FDA Link 10/2020 - 01/2016
2	Messenger RNA (mRNA)IBA 12/2015 - 12/2006
2	Interleukin-6 (Interleukin 6)IBA 12/2015 - 02/2012
2	LipidsIBA 10/2012 - 01/2007
2	Ringer's LactateIBA 02/2012 - 12/2006
2	Immunoglobulin M (IgM)IBA 04/2011 - 03/2011
2	Complement System Proteins (Complement)IBA 04/2011 - 01/2007
2	Carbon Tetrachloride (Tetrachloromethane)IBA 02/2011 - 11/2010
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2006 - 09/2004
1	APTIBA 04/2022
1	Nitroglycerin (Dynamite)FDA LinkGeneric 04/2022
1	Reducing AgentsIBA 03/2022
1	AMP-Activated Protein KinasesIBA 01/2022
1	NF-E2-Related Factor 2IBA 01/2022
1	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 01/2022
1	Interleukin-17 (Interleukin 17)IBA 01/2022
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/2022
1	Cisplatin (Platino)FDA LinkGeneric 12/2021
1	Starch (Cornstarch)IBA 11/2021
1	Hydroxocobalamin FDA Link 10/2021
1	Nitrous Acid (Acid, Nitrous)IBA 10/2021
1	CytochromesIBA 10/2020
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 10/2020
1	Protein Isoforms (Isoforms)IBA 10/2020
1	Cytochrome P-450 CYP2E1 (CYP2E1)IBA 10/2020
1	Cytochrome P-450 CYP1A2 (CYP1A2)IBA 10/2020
1	Peptides (Polypeptides)IBA 10/2019
1	Fibrinogen (Factor I)FDA Link 10/2019
1	Adenosine Diphosphate (ADP)IBA 10/2019
1	dicarboxydine (DCD)IBA 01/2019

Therapy/Procedure

22	Resuscitation 01/2022 - 09/2002
7	Therapeutics 01/2022 - 10/2015
5	Dye Lasers 03/2022 - 03/2017
3	Hemodilution 06/2022 - 05/2003
3	Intravenous Injections 08/2018 - 10/2012
2	Intraosseous Infusions 06/2022 - 01/2020
2	Blood Transfusion (Blood Transfusions) 04/2022 - 01/2022
2	Lasers (Laser) 03/2022 - 03/2017
2	Cesarean Section (Caesarean Section) 11/2021 - 07/2017
2	Ligation 01/2021 - 04/2011
2	Artificial Respiration (Mechanical Ventilation) 01/2020 - 01/2017
1	Euthanasia (Mercy Killing) 04/2022
1	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2022
1	Lung Transplantation 01/2022
1	Erythrocyte Transfusion 01/2021
1	Surgical Hemostasis 01/2021
1	Pneumonectomy (Lung Volume Reduction) 01/2020